Bja 1013
نویسندگان
چکیده
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منابع مشابه
The human agonistic CD40 antibody ADC-1013 eradicates bladder tumors and generates T-cell-dependent tumor immunity.
PURPOSE Local administration of immune-activating antibodies may increase the efficacy and reduce the immune-related adverse events associated with systemic immunotherapy of cancer. Here, we report the development and affinity maturation of a fully human agonistic CD40 antibody (IgG1), ADC-1013. EXPERIMENTAL DESIGN We have used molecular engineering to generate an agonistic antibody with high...
متن کاملThe human CD40 agonistic antibody ADC-1013 generates immune mediated anti-tumor effects in syngeneic tumor models in hCD40 transgenic mice
Local activation of costimulatory pathways by e.g. CD40 activation has been shown to generate powerful systemic anti-tumor responses. Here we report significant antitumor effects obtained with an optimized fully human agonistic CD40 antibody, ADC-1013, in two syngeneic tumor models. An hCD40 transgenic mouse (hCD40tg) strain was used to evaluate the immune mediated anti-tumor effects of ADC-101...
متن کاملADC-1013, an agonistic CD40 antibody optimized for local immunotherapy of cancer
Local administration of immune activating antibodies may increase the efficacy and reduce the immunerelated adverse events associated with systemic immunotherapy of cancer. Here we report the development of a fully human agonistic CD40 antibody (IgG1), ADC1013, which has been optimized for local immunotherapy by increasing potency and tumor retention. ADC1013 activates CD40 receptors on antigen...
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As one of the largest international gatherings of anaesthesiologists, the PostGraduate Assembly (PGA) of the New York State Society of Anesthesiologists is committed to innovative approaches to ongoing education. Based on its commitment to continuing learning and the success of prior supplements, the PGA has again joined with the British Journal of Anaesthesia (BJA) to produce a special BJA/PGA...
متن کاملThe 2014 BJA/PGA special issue: a selection of six educational reviews.
The PostGraduate Assembly (PGA) of the New York State Society of Anesthesiologists (NYSSA), one of the largest international gatherings of anaesthesiologists, continues its strong commitment to innovative approaches to education by once again sponsoring a special issue of the Journal to correspond to the meeting. The PGA has joined with the British Journal of Anaesthesia (BJA) to produce the BJ...
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